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Int J Angiol
DOI: 10.1055/a-2572-0833
Original Article

Cumulative Serum Endothelin-1 and Endothelin-3 Level Predicts 1-year Adverse Cardiac Events after ST-Elevation Acute Myocardial Infarction

Astrid Karina Putri
1   Department of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Sardjito Hospital, Yogyakarta, Indonesia
,
Anggoro Budi Hartopo 
1   Department of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Sardjito Hospital, Yogyakarta, Indonesia
,
Ira Puspitawati
2   Department of Clinical Pathology and Laboratory Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Sardjito Hospital, Yogyakarta, Indonesia
,
Budi Yuli Setianto
1   Department of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Sardjito Hospital, Yogyakarta, Indonesia
› Author Affiliations
Funding This study and publication was supported by: (1) Dana Masyarakat FK-KMK Universitas Gadjah Mada, Yogyakarta, Indonesia (Number: 761/UN1/FKKMK/PPKE/PT/2023), and (2) Academic Excellence Improvement Program Universitas Gadjah Mada, under Grant (Number: 7725/UN1.P.II/Dit-Lit/PT.01.03/2023).
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Abstract

Background

Endothelin-1 (ET-1) and endothelin-3 (ET-3) released in circulation during acute myocardial infarction (AMI) contribute to vasoconstriction, which elevates the severity of the myocardial infarction. This study aims to investigate the role of cumulative ET-1 and ET-3 levels on the major adverse cardiac events (MACE) 1 year after AMI hospitalization.

Materials and Methods

This retrospective cohort study included patients with ST-elevation acute myocardial infarction (STEMI). Baseline data were collected, including sociodemographic characteristics, clinical data, and serum ET-1 and ET-3 levels, measured with ELISA assay. Follow-up was performed 1 year after hospital discharge to identify MACE. A multivariate logistic regression was performed to describe predictors of 1-year MACE.

Results

A total of 81 subjects were enrolled and followed up. Subjects were divided into two groups based on their cumulative ET-1 and ET-3 levels, using a rounded cut-off point of 17.0 ng/mL, produced by the ROC curve for MACE. At 1 year MACE occurred in 24 (29.3%) subjects. A multivariate analysis demonstrated that a cumulative ET-1 and ET-3 level >17.0 ng/mL was independently associated with 1-year MACE (aOR = 5.34, 95% CI: 1.36–21.07, p = 0.017).

Conclusion

A higher cumulative serum ET-1 and ET-3 level at admission predicts MACE in 1 year of follow-up after STEMI.

Keywords

endothelin-1 - endothelin-3 - acute myocardial infarction - major adverse cardiac events


Publication History

Article published online:
30 April 2025

© 2025. International College of Angiology. This article is published by Thieme.

Thieme Medical Publishers, Inc.
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